Vacuum therapy works on the principles of mechanical stimulation and negative pressure, which together produce several beneficial physiological effects. The suction created during therapy causes vasodilation, leading to increased blood circulation that enhances the delivery of oxygen and nutrients essential for tissue repair. It also activates the lymphatic system, promoting the removal of metabolic waste, toxins, and excess fluids, thereby helping to reduce swelling and inflammation. Additionally, the lifting and stretching action on the skin and fascia facilitates myofascial release, easing tension, tightness, and adhesions, which improves overall mobility and flexibility. Vacuum therapy also contributes to pain relief by stimulating mechanoreceptors and modulating nociceptors, thereby decreasing pain perception through neurological pathways. Lastly, the mechanical stimulus from the therapy enhances cellular metabolism, stimulates fibroblast activity, and accelerates the healing of muscles, tendons, and connective tissues, making it an effective tool in rehabilitation and physiotherapy.